関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,1,1-Trimethoxy-2-chloroethane | HCID 144702 | — |
| 反応物 | 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide | HCID 68664388 | — |
| 生成物 | HCID 68663800 | HCID 68663800 | 68% |
反応手順
A mixture of 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide (3.00 g, 8.92 mmol) and 2-chloro-1,1,1-trimethoxyethane (4.70 mL, 24.4 mmol) was stirred at 80° C. for 3 hr. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) and recrystallized from hexane/ethyl acetate to give the title compound (2.39 g, yield 68%) as colorless crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08492378B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-c35c8c783b434e2daf29d1b04cd3c2f2 |
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| 出典メモ | uspto-grants-2013_07 |
|---|
