4-(4-Methoxyphenyl)butyric acid → 2-(1-Benzofuran-5-yl)-5-[3-(4-methoxyphenyl)propyl]-1,3,4-oxadiazole

HRID 452718

反応式

HRID 452718 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([NH:12][NH2:13])=[O:11])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][C:25](O)=O)=[CH:18][CH:17]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:25]([CH2:24][CH2:23][CH2:22][C:19]4[CH:18]=[CH:17][C:16]([O:15][CH3:14])=[CH:21][CH:20]=4)=[N:13][N:12]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

参加物

3

反応物 2

HCID 782804-(4-Methoxyphenyl)butyric acidHCID 686641291-Benzofuran-5-carbohydrazide

生成物 1

HCID 686639332-(1-Benzofuran-5-yl)-5-[3-(4-methoxyphenyl)propyl]-1,3,4-oxadiazole収率 15%

実験手順

In the same manner as in Example 14 and using 1-benzofuran-5-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 4-(4-methoxyphenyl)butyric acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 15%) was obtained as colorless crystals.

出典と根拠

ORDレコード
ord-b0702f4bdb514d6dbdadc40c0726b340
出典データセット
uspto-grants-2013_07
特許番号
US08492378B2

関連ノート

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