関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethyl orthoacetate | HCID 66221 | — |
| 反応物 | 2-[[4-(Methylthio)phenyl]amino]isonicotinohydrazide | HCID 68664110 | — |
| 生成物 | 4-(5-methyl-1,3,4-oxadiazol-2-yl)-N-[4-(methylthio)phenyl]pyridin-2-amine | HCID 68663319 | 80% |
反応手順
A mixture of 2-[[4-(methylthio)phenyl]amino]isonicotinohydrazide (511 mg, 1.86 mmol) and triethyl orthoacetate (10 mL) was stirred at 120° C. overnight. After cooling, the precipitate was collected by filtration and recrystallized from hexane/ethyl acetate to give the title compound (441 mg, yield 80%) as yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08492378B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-88fb69ffd929441a82071c08e8f5a36e |
|---|
| 出典メモ | uspto-grants-2013_07 |
|---|
