Hydrazine hydrate (1:1) → 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide

HRID 452805

反応式

HRID 452805 の反応式
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:14]3[CH:15]=[C:16]([C:19](OC)=[O:20])[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1.O.[NH2:26][NH2:27]>C(O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]([NH:26][NH2:27])=[O:20])[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 68664542Methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate

生成物 1

HCID 686643883-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate (6.80 g, 20.2 mmol) and hydrazine monohydrate (9.92 mL, 202.2 mmol) in ethanol (70 mL) was heated under reflux overnight. After cooling, the precipitate was collected by filtration to give 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide.

後処理

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-56e45ac22a3f4ebeb9cfd5ed9852e527
出典データセット
uspto-grants-2013_07
特許番号
US08492378B2

関連ノート

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