Acetic Acid → HCID 178476642、化合物

HRID 45297

反応式

HRID 45297 の反応式
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].[C:13]([OH:16])(=[O:15])[CH3:14]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:13]([O-:16])(=[O:15])[CH3:14]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

生成物 1

HCID 178476642HCID 178476642、化合物収率 48.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5 L of water, 2 kg (1 equivalent) of metformin hydrochloride and 578 g (1.2 equivalents) of sodium hydroxide were added to 10 L reactor, and stirred for 2 hours at room temperature. Then 1 L (1.45 equivalents) of acetic acid was added for 1 hour, and the mixture was stirred overnight at room temperature. The resulting crystal was washed with acetone-water (12:1) mixture, and then acetone, and dried at 60° C. to obtain 1,112 g of metformin acetate (yield: 48.7%).

後処理

  1. stirringthe mixture was stirred overnight at room temperature
  2. washThe resulting crystal was washed with acetone-water (12:1) mixture
  3. dry with materialacetone, and dried at 60° C.

出典と根拠

ORDレコード
ord-dec2cd9c4d9a4b31a41e029463ef90e6
出典データセット
uspto-grants-2013_09
特許番号
US08541474B2

関連ノート

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