Metformin Hydrochloride → HCID 178476642、化合物
反応式
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.O.O.O.[C:14]([O-:17])(=[O:16])[CH3:15].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:14]([O-:17])(=[O:16])[CH3:15]参加物
4
実験手順
20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).
後処理
- filtrationThen the resulting crystal was filtered
- washwashed with acetone
- customdried at 60° C.
出典と根拠
- ORDレコード
- ord-8f6f02ec54e8446e91f4b5525381d122
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541474B2
反応ノート
読み込み中…