Hydrochloric Acid → Metformin Hydrochloride
反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[ClH:10]>CC(C)=O>[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10]参加物
4
実験手順
500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).
後処理
- filtrationThe resulting crystal was filtered
- washwashed with acetone
- customdried
- temperaturewith heated air at 70° C.
出典と根拠
- ORDレコード
- ord-bb7f28c0f0144c43ad84ff9519be4688
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541474B2
反応ノート
読み込み中…