Hydrochloric Acid → Metformin Hydrochloride

HRID 45306

反応式

HRID 45306 の反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[ClH:10]>CC(C)=O>[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178484382HCID 178484382、化合物

生成物 1

HCID 14219Metformin Hydrochloride収率 76.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

後処理

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. customdried
  4. temperaturewith heated air at 70° C.

出典と根拠

ORDレコード
ord-bb7f28c0f0144c43ad84ff9519be4688
出典データセット
uspto-grants-2013_09
特許番号
US08541474B2

関連ノート

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