Benzylamine → 2-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide

HRID 45310

反応式

HRID 45310 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.C(N)C1C=CC=CC=1.[NH2:18][C:19]1[S:20][C:21]([C:25](O)=[O:26])=[C:22]([CH3:24])[N:23]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][C:25]([C:21]2[S:20][C:19]([NH2:18])=[N:23][C:22]=2[CH3:24])=[O:26])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 7504BenzylamineHCID 660364-ChlorobenzylamineHCID 8322432-Amino-4-methyl-thiazole-5-carboxylic acid

生成物 1

HCID 627933982-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide収率 15%

実験手順

Following the procedure as described in Preparation 1, making variation only as required to use 4-chlorobenzylamine to replace benzylamine to react with 2-amino-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a white solid in 15% yield; 1H NMR (CD3OD, 300 MHz) δ 7.26-7.32 (m, 4H), 4.41 (s, 2H), 2.38 (s, 3H). MS (ES+) m/z 282.1 (M+1).

後処理

  1. customas described in Preparation 1

出典と根拠

ORDレコード
ord-71a0d48e151b4f408c37694c52a3b666
出典データセット
uspto-grants-2013_09
特許番号
US08541457B2

関連ノート

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