Potassium Hydroxide → 4-Benzyloxybenzamide

HRID 453103

反応式

HRID 453103 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:17].[K+]>C(O)(C)(C)C.[Cl-].[Na+].O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH2:14])=[O:17])=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 5613714-Benzyloxybenzonitrile

生成物 1

HCID 27264314-Benzyloxybenzamide収率 101.3%

試薬・触媒・溶媒 2

HCID 6386tert-Butanol溶媒HCID 57417360Sodium chloride; water溶媒

反応条件

温度
78 °C

実験手順

To a solution of 4-benzyloxybenzonitrile (0.61 g, 2.91 mmol) in 15 ml of tert-butanol was added fine powder of KOH (1.22 g, 21.78 mmol) and the resulting reaction mixture was refluxed for 4 h at 78° C. After the completion of the reaction (TLC monitoring), added brine solution and extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum, to get the product (0.67 g) that was used as such for the next step.

後処理

  1. customthe resulting reaction mixture
  2. customAfter the completion of the reaction (TLC monitoring)
  3. extractionextracted with ethyl acetate (3×50 ml)
  4. dry with materialThe combined organic layer was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-601a0271a430444ca570020d1a338b7c
出典データセット
uspto-grants-2013_07
特許番号
US08492414B2

関連ノート

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