Hydrochloric Acid → 2-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride

HRID 453288ノート

反応式

HRID 453288 の反応式
[ClH:1].[C:2]1([C:8]2[S:9][C:10]([CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:11]([C:13]([O:15]C(C)(C)C)=[O:14])[N:12]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1>[ClH:1].[C:2]1([C:8]2[S:9][C:10]([CH2:20][N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67425601Tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate

生成物 1

HCID 674258692-Phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride収率 82%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Concentrated HCl (2.8 ml, 33.9 mmol) was added to a solution of tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate (2.1 g, 6.1 mmol) in THF (30 ml). The mixture was stirred at rt overnight, and concentrated in vacuo to give 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride (1.5 g, 82% yield).

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-dd6ed0a6c7d747779ad1d21e8251e6cb
出典データセット
uspto-grants-2013_07
特許番号
US08492401B2

反応ノート

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