N-(1-Methyl-4-piperidinyl)-5-nitro-2-pyrimidinamine → HCID 24823424、化合物

HRID 453359ノート

反応式

HRID 453359 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]2[N:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][N:10]=2)[CH2:4][CH2:3]1>CCOC(C)=O.CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:9]2[N:10]=[CH:11][C:12]([NH2:15])=[CH:13][N:14]=2)[CH2:6][CH2:7]1

参加物

5

反応物 1

HCID 24823901N-(1-Methyl-4-piperidinyl)-5-nitro-2-pyrimidinamine

生成物 1

HCID 24823424HCID 24823424、化合物

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

The crude N-(1-methylpiperidin-4-yl)-5-nitropyrimidin-2-amine was combined with 10% Pd/C (500 mg) in EtOAc (8 mL) and MeOH (20 mL) was added. The mixture was purged with H2 and allowed to stir under 1 atm H2 overnight. Filtration through a pad of celite and concentration afforded N2-(1-methylpiperidin-4-yl)pyrimidine-2,5-diamine 17 as a tan solid, which may be used without further purification. MS: m/z found 285 [MH+].

後処理

  1. additionwas added
  2. customThe mixture was purged with H2
  3. filtrationFiltration
  4. concentrationthrough a pad of celite and concentration

出典と根拠

ORDレコード
ord-2174d5e7dc5b4a4ca04a4f702a9ef91b
出典データセット
uspto-grants-2013_07
特許番号
US08492404B2

反応ノート

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