m-Chloroperbenzoic acid → Acetic acid 4-benzyloxy-2-((R)-1-oxiranylmethoxy)phenyl ester

反応式

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12](C(=O)C)=[C:11]([O:18][CH2:19][C@H:20]2[CH2:22][O:21]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=CC=[C:26]([C:30]([O:32]O)=[O:31])C=1.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:32][C:30](=[O:31])[CH3:26])=[C:11]([O:18][CH2:19][C@H:20]2[CH2:22][O:21]2)[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

実験手順

To a stirred solution of 1-[4-benzyloxy-2-((R)-1-oxiranylmethoxy)phenyl]ethanone (1.62 g, 5.43 mmol) in DCM (60 ml) was added m-chloroperbenzoic acid (2.15 g) and solid NaHCO3 (3.24 g). Stirring was continued at 40° C. for 1 h. The mixture was filtered and the filtrate was washed once with 10% NaHSO4 solution and then twice with NaHCO3 solution. The organic layer was washed with water and brine, dried with Na2SO4. The solvent was removed under reduced pressure. The crude product obtained (1.34 g) was sufficiently pure for the next step.