Hydrochloric Acid → 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-pyrrolidine-3-carboxylic acid methyl ester

温度

0 °C

A solution containing 300 mg (1.03 mmol) of 1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester in dry tetrahydrofuran (4 mL) was cooled to 0° C. under nitrogen. After adding 4 mL of 1M BH3-tetrahydrofuran solution (4.12 mmol), the reaction mixture was allowed to warm to room temperature and it was stirred for 5 h. Decomposition of the boron complexes was effected by addition of 3 mL of methanol and 3 mL of 6 M HCl-solution followed by stirring the mixture at 40° C. for ½ h. Tetrahydrofuran was evaporated off under vacuum. The residue was dissolved in 50 mL of water and the pH of the solution was adjusted to 10 using 1M Na2CO3 solution. The water phase was extracted with ethyl acetate (3×25 mL), and the combined organic phases were dried over anhydrous sodium sulfate, filtered, and evaporated to dryness. The crude product was purified by column chromatography (silica gel, heptane/ethyl acetate, 7:3).

1. temperatureto warm to room temperature
2. stirringby stirring the mixture at 40° C. for ½ h
3. customTetrahydrofuran was evaporated off under vacuum
4. dissolutionThe residue was dissolved in 50 mL of water
5. extractionThe water phase was extracted with ethyl acetate (3×25 mL)
6. dry with materialthe combined organic phases were dried over anhydrous sodium sulfate
7. filtrationfiltered
8. customevaporated to dryness
9. customThe crude product was purified by column chromatography (silica gel, heptane/ethyl acetate, 7:3)

ORDレコード

ord-18652c8fe31344f5b052a735010d2a7e

出典データセット

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08492549B2