Sodium Hydroxide → 2-(6-(7-Methyl-1-oxoisoindolin-2-yl)-1H-indol-1-yl)acetic acid

HRID 453864ノート

反応式

HRID 453864 の反応式
[OH-].[Na+].[CH3:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[C:11](=[O:13])[N:10]([C:14]1[CH:22]=[C:21]3[C:17]([CH:18]=[CH:19][N:20]3[CH2:23][C:24]([O:26]CC)=[O:25])=[CH:16][CH:15]=1)[CH2:9]2>O.C1COCC1.CO>[CH3:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[C:11](=[O:13])[N:10]([C:14]1[CH:22]=[C:21]3[C:17]([CH:18]=[CH:19][N:20]3[CH2:23][C:24]([OH:26])=[O:25])=[CH:16][CH:15]=1)[CH2:9]2

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 59473657ethyl 2-(6-(7-methyl-1-oxoisoindolin-2-yl)-1H-indol-1-yl)acetate

生成物 1

HCID 594736892-(6-(7-Methyl-1-oxoisoindolin-2-yl)-1H-indol-1-yl)acetic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 21899815MeOH tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

NaOH (1.86 mmol, 1.3 equiv.), dissolved in water (6 ml), was added to a solution of ethyl 2-(6-(7-methyl-1-oxoisoindolin-2-yl)-1H-indol-1-yl)acetate (1.44 mmol, 1 equiv.) in THF/MeOH (1:1, 5 ml), and the mixture was stirred for 2 h at 25° C. The reaction solution was concentrated under reduced pressure, and the aqueous residue was adjusted to pH 3 with 1 M HCl and extracted with ethyl acetate (3×50 ml). The combined organic phases were dried over Na2SO4 and concentrated under reduced pressure. Yield: quantitative

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. extractionextracted with ethyl acetate (3×50 ml)
  3. dry with materialThe combined organic phases were dried over Na2SO4
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-3dadbd3fa1dc4eb9ba6bde14b16b80b9
出典データセット
uspto-grants-2013_07
特許番号
US08492559B2

反応ノート

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