Trifluoroacetic acid → 2-(6-(10-Chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetic acid

HRID 453873ノート

反応式

HRID 453873 の反応式
[Cl:1][C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]2[CH2:11][CH2:12][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH:20]=[CH:21][N:22]4[CH2:25][C:26]([O:28]C(C)(C)C)=[O:27])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]2[CH2:11][CH2:12][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH:20]=[CH:21][N:22]4[CH2:25][C:26]([OH:28])=[O:27])=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]=12

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59473664tert-Butyl 2-(6-(10-chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetate

生成物 1

HCID 594736922-(6-(10-Chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetic acid収率 91%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

tert-Butyl 2-(6-(10-chloro-1-oxo-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-1H-indol-1-yl)acetate (2.22 mmol, 1.0 equiv.) was dissolved in DCM (15 ml); TFA (3 ml) was added, and the mixture was stirred for 2 h at 25° C. The solvent was concentrated under reduced pressure, and the residue was taken up in DCM (60 ml), washed with water (25 ml) and sat. NaCl solution (25 ml), dried over Na2SO4 and concentrated to dryness under reduced pressure. Yield: 91%

後処理

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washwashed with water (25 ml) and sat. NaCl solution (25 ml)
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-83328893d0c841d88cfda820013150b0
出典データセット
uspto-grants-2013_07
特許番号
US08492559B2

反応ノート

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