Hydrochloric Acid → HCID 67369868、化合物

HRID 453891ノート

反応式

HRID 453891 の反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][C:12]([N:20]([CH3:22])[CH3:21])([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C.CCOC(C)=O.CCCCCC>C(Cl)(Cl)Cl>[ClH:1].[ClH:1].[CH3:21][N:20]([CH3:22])[C:12]1([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 21226206Ethyl acetate hexaneHCID 57831240HCID 57831240、化合物

生成物 1

HCID 67369868HCID 67369868、化合物収率 98%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

HCl gas was passed through a solution of 6 g (1 eq.) tert-butyloxycarbonyl-4-(dimethylamino)-4-(thiophen-2-yl)piperidine in 120 ml chloroform at 0° C. for 1 h. The reaction course was monitored by thin-layer chromatography (75% EtOAc/hexane). Once the conversion was complete, the solvent was removed under reduced pressure and 5.3 g (98%) of product were obtained in the form of a white solid.

後処理

  1. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-082771a2dfbe4f7baa2ca51400232ab8
出典データセット
uspto-grants-2013_07
特許番号
US08492559B2

反応ノート

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