7-Benzyloxy-6-methoxy-4-phenoxyquinazoline → 7-Hydroxy-6-methoxy-4-phenoxyquinazoline

HRID 453983ノート

反応式

HRID 453983 の反応式
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27]

参加物

3

反応物 1

HCID 218748147-Benzyloxy-6-methoxy-4-phenoxyquinazoline

生成物 1

HCID 1354961377-Hydroxy-6-methoxy-4-phenoxyquinazoline収率 96%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (36.95 g, 105.5 mmol) was suspended in TFA (420 ml) and heated at reflux for 3 hours. The reaction mixture was allowed to cool and evaporated under vacuum. The residue was stirred mechanically in water then basified with saturated aqueous sodium hydrogen carbonate solution and stirred overnight. The water was decanted and the solid suspended in acetone. After stirring the white solid was collected by filtration, washed with acetone and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (26.61 g, 96%).

後処理

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. temperatureto cool
  4. customevaporated under vacuum
  5. stirringstirred overnight
  6. customThe water was decanted
  7. stirringAfter stirring the white solid
  8. filtrationwas collected by filtration
  9. washwashed with acetone
  10. customdried

出典と根拠

ORDレコード
ord-3b2faee5f001413abb79fc6904f74e69
出典データセット
uspto-grants-2013_07
特許番号
US08492560B2

反応ノート

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