Dichloromethane → HCID 22030751、化合物

HRID 454217ノート

反応式

HRID 454217 の反応式
[C:1]([CH2:4][C:5]1[C:6]([F:15])=[C:7]([F:14])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])(=[O:3])[CH3:2].O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3].[CH:34](OC)(OC)[O:35]C.[CH2:41](Cl)Cl>>[F:14][C:7]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:5]([CH2:4][C:1]([O:35][CH3:34])([O:3][CH3:41])[CH3:2])[C:6]=1[F:15]

参加物

5

反応物 4

HCID 6344DichloromethaneHCID 9005Trimethyl orthoformateHCID 142688761-(2,3-Difluoro-6-nitrophenyl)propan-2-oneHCID 71586775Bentonite

生成物 1

HCID 22030751HCID 22030751、化合物収率 88%

実験手順

A solution of 3-acetylmethyl-1,2-difluoro-4-nitrobenzene (500 mg, 2.3 mmol) in methylene chloride (5 ml) containing montmorillonite K10 (1 g) and trimethyl orthoformate (5 ml) was stirred for 24 hours at ambient temperature. The solid was filtered, washed with methylene chloride and the filtrate was evaporated to give 1,2-difluoro-3-(2,2-dimethoxypropyl)-4-nitrobenzene (534 mg, 88%).

後処理

  1. filtrationThe solid was filtered
  2. washwashed with methylene chloride
  3. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-1178c177a3314f07bb24ac25871386d9
出典データセット
uspto-grants-2013_07
特許番号
US08492560B2

反応ノート

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