Sodium Hydroxide → 5-(Pyrimidin-2-yl)pyridine-3-carboxylic acid

HRID 454526ノート

反応式

HRID 454526 の反応式
[OH-].[Na+].[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[C:9]1[CH:10]=[C:11]([C:15]([O:17]C)=[O:16])[CH:12]=[N:13][CH:14]=1>O1CCOCC1.CO>[N:3]1[CH:8]=[CH:7][CH:6]=[N:5][C:4]=1[C:9]1[CH:10]=[C:11]([C:15]([OH:17])=[O:16])[CH:12]=[N:13][CH:14]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 66989995Methyl 5-(pyrimidin-2-yl)pyridine-3-carboxylate

生成物 1

HCID 669912565-(Pyrimidin-2-yl)pyridine-3-carboxylic acid収率 25%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A 2 mol/L aqueous solution of sodium hydroxide (0.21 mL) was added to a solution mixture of the obtained methyl 5-(pyrimidin-2-yl)pyridine-3-carboxylate (30 mg) in dioxane (0.3 mL) and methanol (0.3 mL) at room temperature, followed by stirring at the same temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and water and toluene were added to the residue. The aqueous layer was separated and adjusted to a pH of 3.8 with 1 mol/L hydrochloric acid. The solid substance was collected by filtration to obtain 7.0 mg of 5-(pyrimidin-2-yl)pyridine-3-carboxylic acid as a white solid.

後処理

  1. customThe solvent was evaporated under reduced pressure, and water and toluene
  2. additionwere added to the residue
  3. customThe aqueous layer was separated
  4. filtrationThe solid substance was collected by filtration

出典と根拠

ORDレコード
ord-73f62f057064405a985188929029d79c
出典データセット
uspto-grants-2013_07
特許番号
US08492582B2

反応ノート

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