Citric Acid → 5-(Furan-3-yl)pyridine-3-carboxylic acid

HRID 454527ノート

反応式

HRID 454527 の反応式
[OH-].[Na+].[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([O:16]C)=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CO>[O:3]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:14]([OH:16])=[O:15])[CH:11]=[N:12][CH:13]=2)=[CH:4]1

参加物

5

反応物 3

HCID 311Citric AcidHCID 14798Sodium HydroxideHCID 66989989Methyl 5-(furan-3-yl)pyridine-3-carboxylate

生成物 1

HCID 639483225-(Furan-3-yl)pyridine-3-carboxylic acid収率 65.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 4 mol/L aqueous solution of sodium hydroxide (2.0 mL) was added to a methanol (10 mL) solution of methyl 5-(furan-3-yl)pyridine-3-carboxylate (0.54 g) at room temperature, followed by stirring at the same temperature for 2 hours and 50 minutes. A 10% aqueous solution of citric acid (8 mL) was added to the reaction mixture at room temperature, and the solvent was evaporated under reduced pressure. Water was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.33 g of 5-(furan-3-yl)pyridine-3-carboxylic acid as a light yellow solid.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionWater was added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

出典と根拠

ORDレコード
ord-0f5757db9a114f4ea4c086d54b75ce06
出典データセット
uspto-grants-2013_07
特許番号
US08492582B2

反応ノート

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