Ammonium Chloride → 2-(3-Bromophenyl)pyridine
反応式
C(O[C:9]1[C:14](C=O)=[CH:13][CH:12]=[CH:11][C:10]=1[C:17]1C=[CH:21][CH:20]=[CH:19][CH:18]=1)C1C=CC=CC=1.C[Mg][Br:25].[Cl-].[NH4+:27]>O1CCCC1>[Br:25][C:14]1[CH:9]=[C:10]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:27]=2)[CH:11]=[CH:12][CH:13]=1参加物
5
実験手順
A solution of 2-(benzyloxy)biphenyl-3-carbaldehyde (5.55 g, 20 mmol) in anhydrous tetrahydrofuran (100 mL) was stirred under nitrogen on an water bath at room temperature and 3M methyl magnesium bromide in tetrahydrofuran (10 mL, 30 mmol, 1.5 equiv.) was added. Stirring was continued at room temperature for 40 min. The reaction mixture was poured onto saturated ammonium chloride (200 mL) and extracted with ethyl acetate (2×200 mL). The organic extract was washed with water (100 mL), dried over sodium sulfate and stripped to afford pure 1 (6 g, 98%).
後処理
- extractionextracted with ethyl acetate (2×200 mL)
- extractionThe organic extract
- washwas washed with water (100 mL)
- dry with materialdried over sodium sulfate
出典と根拠
- ORDレコード
- ord-f9f5bd13bb0c4058897facaece17fc47
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541522B2
反応ノート
読み込み中…