Trifluoroacetic acid → 4-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

HRID 454732ノート

反応式

HRID 454732 の反応式
FC(F)(F)C(O)=O.[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([O:20]C(C)(C)C)=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([OH:20])=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 58508784Tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate

生成物 1

HCID 585086024-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

実験手順

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and methanol was added to the obtained residue. The solid substance was collected by filtration to obtain 53 mg of 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

後処理

  1. customThe solvent was evaporated under reduced pressure, and methanol
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

出典と根拠

ORDレコード
ord-7de150240329499c82a64376f700eb42
出典データセット
uspto-grants-2013_07
特許番号
US08492582B2

反応ノート

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