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HRID 454814作成日：2026年10月26日

Dimethylamine methanol → 2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiophene

https://huagongshe.com/reaction/454814

反応式

関与物質

役割名称HCID仕込み量
反応物Dimethylamine methanolHCID 22497844—
反応物2-(2-Chloropyrimidine-4-yl)-6-(2-fluoroethoxy)benzothiopheneHCID 86646556—
生成物2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiopheneHCID 4694772693.3%

反応手順

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiophene (1-36, 77 mg, 93%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(2-fluoroethoxy)benzothiophene (105b, 80 mg, 0.26 mmol) obtained in Preparation Example 20 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.26 mL, 0.52 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08497260B2
出典データセットuspto-grants-2013_07
ORD IDord-96170d9aa23544a8a1f48cc3111b62dc
出典メモuspto-grants-2013_07