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HRID 454816作成日：2026年10月26日

Monomethylamine methanol → 2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene

https://huagongshe.com/reaction/454816

反応式

関与物質

役割名称HCID仕込み量
反応物Monomethylamine methanolHCID 57454252—
反応物2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiopheneHCID 86646557—
生成物2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiopheneHCID 4694772881%

反応手順

2-[2-(N-Monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-38, 56 mg, 81%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M methylamine methanol solution (NH2Me in MeOH, 0.17 mL, 0.34 mmol).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08497260B2
出典データセットuspto-grants-2013_07
ORD IDord-5a8dd2395eee48f8be36faf4892656d1
出典メモuspto-grants-2013_07