Dimethylamine methanol → HCID 46947729、化合物

HRID 454817

反応式

HRID 454817 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1.CO.[CH3:24][NH:25][CH3:26]>>[CH3:24][N:25]([C:2]1[N:7]=[C:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH:5]=[CH:4][N:3]=1)[CH3:26]

参加物

3

反応物 2

HCID 22497844Dimethylamine methanolHCID 866465572-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene

生成物 1

HCID 46947729HCID 46947729、化合物収率 70%

実験手順

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-39, 50 mg, 70%) was prepared in the same manner as in Example 36 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoro propoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.17 mL, 0.34 mmol).

後処理

  1. customobtained in Preparation Example 21

出典と根拠

ORDレコード
ord-88bf5b9b36a1453f9c4fe1d63f7373aa
出典データセット
uspto-grants-2013_07
特許番号
US08497260B2

関連ノート

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