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Dimethylamine methanol → 2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylamine methanol | HCID 22497844 | — |
| 反応物 | 2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 86646557 | — |
| 生成物 | 2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene | HCID 46947729 | 70% |
反応手順
2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-39, 50 mg, 70%) was prepared in the same manner as in Example 36 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoro propoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.17 mL, 0.34 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497260B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-88bf5b9b36a1453f9c4fe1d63f7373aa |
| 出典メモ | uspto-grants-2013_07 |