2-(Methylamino)ethanol → N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-2-(2-(methylamino)ethoxy)pyrimidin-4-amine

HRID 455106

反応式

HRID 455106 の反応式
ClC1C=CC2N(C(CNC3N=C([O:26][C@@H:27]4C[CH2:30][N:29](C)[CH2:28]4)C=CN=3)=C(C3C=CC(F)=CC=3)N=2)C=1.Cl[C:34]1[N:39]=[C:38]([NH:40][CH2:41][C:42]2[N:46]3[CH:47]=[CH:48][CH:49]=[CH:50][C:45]3=[N:44][C:43]=2[C:51]2[CH:56]=[CH:55][C:54]([Cl:57])=[CH:53][CH:52]=2)[CH:37]=[CH:36][N:35]=1.CNCCO>>[Cl:57][C:54]1[CH:55]=[CH:56][C:51]([C:43]2[N:44]=[C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][N:46]3[C:42]=2[CH2:41][NH:40][C:38]2[CH:37]=[CH:36][N:35]=[C:34]([O:26][CH2:27][CH2:28][NH:29][CH3:30])[N:39]=2)=[CH:52][CH:53]=1

参加物

4

反応物 3

HCID 80162-(Methylamino)ethanolHCID 58337026(R)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amineHCID 866551232-chloro-N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-amine

生成物 1

HCID 67027679N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-2-(2-(methylamino)ethoxy)pyrimidin-4-amine

実験手順

The title compound was prepared in the same fashion as that described for compound 183 from 2-chloro-N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-amine and 2-(methylamino)ethanol. M/e+ 409 for C21H22ClN6O (M+H)+; 1H-NMR (400 MHz, CD3OD) δ 8.61 (s, 1H), 7.74 (d, J=8.4 Hz, 2H), 7.68 (d, J=6.2 Hz, 1H), 7.50 (t, J=7.3 Hz, 2H), 7.43 (d, J=7.3 Hz, 1H), 7.39 (m, 1H), 5.84 (d, J=6.2 Hz, 2H), 5.08 (d, J=8.8 Hz, 2H), 3.74 (m, 2H), 3.17 (s, 3H) ppm.

出典と根拠

ORDレコード
ord-32879a2cfd0c4394922cdf50cb036e03
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

関連ノート

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