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2-(Methylamino)ethanol → N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-2-(2-(methylamino)ethoxy)pyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylamino)ethanol | HCID 8016 | — |
| 反応物 | (R)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amine | HCID 58337026 | — |
| 反応物 | 2-chloro-N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-amine | HCID 86655123 | — |
| 生成物 | N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-2-(2-(methylamino)ethoxy)pyrimidin-4-amine | HCID 67027679 | — |
反応手順
The title compound was prepared in the same fashion as that described for compound 183 from 2-chloro-N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-amine and 2-(methylamino)ethanol. M/e+ 409 for C21H22ClN6O (M+H)+; 1H-NMR (400 MHz, CD3OD) δ 8.61 (s, 1H), 7.74 (d, J=8.4 Hz, 2H), 7.68 (d, J=6.2 Hz, 1H), 7.50 (t, J=7.3 Hz, 2H), 7.43 (d, J=7.3 Hz, 1H), 7.39 (m, 1H), 5.84 (d, J=6.2 Hz, 2H), 5.08 (d, J=8.8 Hz, 2H), 3.74 (m, 2H), 3.17 (s, 3H) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497278B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-32879a2cfd0c4394922cdf50cb036e03 |
| 出典メモ | uspto-grants-2013_07 |