Methylamine → 4-chloro-N-methylbutane-1-sulfonamide

To a solution of 4-chlorobutane-1-sulfonyl chloride (117 mmol) and triethyl amine (117 mmol) in dichloro methane (250 ml) at 0° C. was added a 2M solution of methyl amine in THF (117 mmol) dropwise. The mixture was allowed to warm to room temperature with stirring overnight. The organic solution was washed with H2O and extracted with CH2Cl2, dried over MgSO4 and filtered. The solution was concentrated. The product was used without further purification.

1. washThe organic solution was washed with H2O
2. extractionextracted with CH2Cl2
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationThe solution was concentrated
6. customThe product was used without further purification

ORDレコード

ord-973a1751c9bc4dd493d5322be9346561

出典データセット

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08497270B2