Hydrochloric Acid → Hydrochloric Acid

HRID 455351ノート

反応式

HRID 455351 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C:2]=12.[ClH:14]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][C@@H:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C@H:2]12.[ClH:14]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 12226515Azafluorene

生成物 2

HCID 313Hydrochloric AcidHCID 58123900cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒2 回HCID 702Ethanol溶媒

実験手順

A mixture of 9H-indeno[2,1-b]pyridine (0.20 g), PtO2 (70 mg), concentrated aqueous hydrochloric acid (0.1 mL), and ethanol (10 mL) is shaken under hydrogen atmosphere (2 bar) at room temperature for 16 h (in case the transformation is not complete after this time another portion of PtO2 (30 mg) is added and shaking under hydrogen is continued until complete). The catalyst is separated by filtration and the solvent is evaporated to give the crude title compound as its hydrochloric acid salt that is used without further purification. Yield: 0.25 g (crude); Mass spectrum (ESI+): m/z=174 [M+H]+.

後処理

  1. additionis added
  2. stirringshaking under hydrogen
  3. customThe catalyst is separated by filtration
  4. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-a291dfe5e6b84b33b800681e91238d5f
出典データセット
uspto-grants-2013_07
特許番号
US08497281B2

反応ノート

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