Water → (S)-7-(3,3-dimethylbut-1-ynyl)-3-(2-fluoropyridin-4-yl)-2',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,3'-[1,4]oxazin]-5'-amine

反応式

Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:22]#[C:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1.[F:28][C:29]1[CH:34]=[C:33](B(O)O)[CH:32]=[CH:31][N:30]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].O>CC1OCCC1.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.CC(P(C(C)(C)C)C1C=CC(N(C)C)=CC=1)(C)C.Cl[Pd]Cl>[CH3:25][C:24]([CH3:27])([CH3:26])[C:23]#[C:22][C:12]1[CH:13]=[C:14]2[C@:15]3([N:20]=[C:19]([NH2:21])[CH2:18][O:17][CH2:16]3)[C:4]3[C:5](=[N:6][CH:7]=[C:2]([C:33]4[CH:32]=[CH:31][N:30]=[C:29]([F:28])[CH:34]=4)[CH:3]=3)[O:8][C:9]2=[CH:10][CH:11]=1