Ethyl Acetate → (S)-N-((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-hydroxyethyl)-2-methylpropane-2-sulfinamide

HRID 455691ノート

反応式

HRID 455691 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH2:36][O:37][CH3:38])=[C:6]([C@@:8]([C:21]2[CH:26]=[C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[N:24]=[C:23]([F:33])[C:22]=2[Cl:34])([NH:14][S@:15]([C:17]([CH3:20])([CH3:19])[CH3:18])=[O:16])[C:9](OCC)=[O:10])[CH:7]=1.CC(C[AlH]CC(C)C)C.C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+].CCOC(C)=O>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH2:36][O:37][CH3:38])=[C:6]([C@:8]([NH:14][S@:15]([C:17]([CH3:18])([CH3:19])[CH3:20])=[O:16])([C:21]2[CH:26]=[C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[N:24]=[C:23]([F:33])[C:22]=2[Cl:34])[CH2:9][OH:10])[CH:7]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 14487Diisobutylaluminum hydride3 回HCID 9855836Potassium sodium tartarateHCID 86658387(S)-ethyl 2-(5-bromo-2-(methoxymethoxy)phenyl)-2-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-((S)-1,1-dimethylethylsulfinamido)acetate

生成物 1

HCID 67440021(S)-N-((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-hydroxyethyl)-2-methylpropane-2-sulfinamide収率 57.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of (S)-ethyl 2-(5-bromo-2-(methoxymethoxy)phenyl)-2-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-((S)-1,1-dimethylethylsulfinamido)acetate (3.56 g, 5.59 mmol) in THF (60 mL) was cooled to 0° C. and treated drop wise with DIBAL (1M in THF) (22.36 mL, 22.36 mmol) under nitrogen atmosphere. After 1 h additional 10 mL DIBAL solution were added at RT. After 12 h at RT additional 10 mL DIBAL solution were added. After 30 min aqueous saturated solution of potassium sodium tartrate was added, followed by EtOAc. The reaction mixture was allowed to stir vigorously for 1 h. The organic phase was separated, washed with aqueous saturated solution of potassium sodium tartrate and dried over MgSO4. The solvent was removed under reduced pressure and the crude material was purified by silica gel chromatography (20-100% EtOAc/hexane) to provide 1.90 g of (S)—N—((S)-1-(5-bromo-2-(methoxymethoxy)phenyl)-1-(3-chloro-2-fluoro-6-morpholinopyridin-4-yl)-2-hydroxyethyl)-2-methylpropane-2-sulfinamide.

後処理

  1. customThe organic phase was separated
  2. washwashed with aqueous saturated solution of potassium sodium tartrate
  3. dry with materialdried over MgSO4
  4. customThe solvent was removed under reduced pressure
  5. customthe crude material was purified by silica gel chromatography (20-100% EtOAc/hexane)

出典と根拠

ORDレコード
ord-9af7af164d6c4cc482ce20f08374690c
出典データセット
uspto-grants-2013_07
特許番号
US08497264B2

反応ノート

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