Hydrazine hydrate (1:1) → 1-(Quinolin-6-yl)cyclopropanecarbohydrazide

HRID 456114ノート

反応式

HRID 456114 の反応式
C[O:2][C:3]([C:5]1([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[CH:13][CH:12]=[CH:11]3)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>CO>[N:14]1[C:15]2[C:10](=[CH:9][C:8]([C:5]3([C:3]([NH:19][NH2:20])=[O:2])[CH2:7][CH2:6]3)=[CH:17][CH:16]=2)[CH:11]=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 58190477Methyl 1-(quinolin-6-yl)cyclopropanecarboxylate

生成物 1

HCID 669271581-(Quinolin-6-yl)cyclopropanecarbohydrazide収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1-quinolin-6-yl-cyclopropanecarboxylic acid methyl ester (513 mg, 2.26 mmol) and hydrazine monohydrate (3.39 g, 67.7 mmol) in methanol (5 mL) was heated under reflux overnight. After cooling, the solvent was removed in vacuo to afford 513 mg (100%) of the title compound and used without further purification. LCMS (method A): [MH]+=228, tR=2.88 min.

後処理

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-a43a402029b649049326699f8de4c99d
出典データセット
uspto-grants-2013_07
特許番号
US08497368B2

反応ノート

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