Benzylamine → (3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione
反応式
[C:1]([OH:10])(=O)[C@@H:2]([C@H:4]([C:6](O)=[O:7])[OH:5])[OH:3].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CC1C=CC=CC=1C>[CH2:11]([N:18]1[C:6](=[O:7])[C@H:4]([OH:5])[C@@H:2]([OH:3])[C:1]1=[O:10])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
4
実験手順
L-Tartaric acid (90 g, 600 mmol) and benzylamine (64.3 g, 600 mmol) were mixed in 400 mL of o-xylene and the mixture was refluxed 14 hours with a Dean-Stark trap. The pellet was filtered off and the compound was crystallized from hot EtOH (1600 mL). The formed crystals were washed with cold hexane to afford the title compound.
後処理
- temperaturethe mixture was refluxed 14 hours with a Dean-Stark trap
- filtrationThe pellet was filtered off
- customthe compound was crystallized from hot EtOH (1600 mL)
- washThe formed crystals were washed with cold hexane
出典と根拠
- ORDレコード
- ord-4a13d574e19143a398a636b59ee0b19a
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08497383B2
反応ノート
読み込み中…