N-(4-Hydroxybenzoyl)glycine tert-butyl ester → N-[4-(2-Cyclopenta-2-en-1-ylethoxy)benzoyl]glycine

HRID 456303

反応式

HRID 456303 の反応式
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[CH:19]1([CH2:24][CH2:25]O)[CH2:23][CH2:22][CH:21]=[CH:20]1>>[CH:19]1([CH2:24][CH2:25][O:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=2)[CH2:23][CH2:22][CH:21]=[CH:20]1

参加物

3

反応物 2

HCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl esterHCID 109644442-Cyclopentene-1-ethanol

生成物 1

HCID 66812182N-[4-(2-Cyclopenta-2-en-1-ylethoxy)benzoyl]glycine収率 72%

実験手順

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (157 mg, 0.625 mmol) prepared in Example 1 (1a) and 2-cyclopenta-2-en-1-ylethanol (which is the compound disclosed in J. Org. Chem., (2000), 65, 4241-4250, 85 mg, 0.75 mmol) to give 128 mg of the title compound (white powder, yield: 72%).

出典と根拠

ORDレコード
ord-177f8dac70334486b69579511e496689
出典データセット
uspto-grants-2013_07
特許番号
US08497397B2

関連ノート

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