Methylamine → 3-hydroxy-N-methylbenzamide

HRID 456396

反応式

HRID 456396 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:11][NH2:12]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:12][CH3:11])=[O:6]

参加物

3

反応物 2

HCID 6329MethylamineHCID 74203-Hydroxybenzoic Acid

生成物 1

HCID 3537103-hydroxy-N-methylbenzamide収率 91.5%

実験手順

A mixture of 3-hydroxybenzoic acid (1.3 g, 9.4 mmol) and a ethanolic methylamine solution (33%, 1.5 ml, 12.1 mmol) were stirred at 60° C. for 48 h, then the solvent was evaporated in vacuo, and the residue redissolved in a small volume of ethanol. The product precipitated from the solution by the addition of ethyl acetate. The precipitate was collected by filtration and dried to give the subtitled compound (1.3 g, 91%).

後処理

  1. customthe solvent was evaporated in vacuo
  2. dissolutionthe residue redissolved in a small volume of ethanol
  3. customThe product precipitated from the solution by the addition of ethyl acetate
  4. filtrationThe precipitate was collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-0a298d99e03a41c588c18607c8b057ee
出典データセット
uspto-grants-2007_03
特許番号
US07186718B2

関連ノート

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