Methylamine → 3-hydroxy-N-methylbenzamide
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].[CH3:11][NH2:12]>>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:12][CH3:11])=[O:6]参加物
3
実験手順
A mixture of 3-hydroxybenzoic acid (1.3 g, 9.4 mmol) and a ethanolic methylamine solution (33%, 1.5 ml, 12.1 mmol) were stirred at 60° C. for 48 h, then the solvent was evaporated in vacuo, and the residue redissolved in a small volume of ethanol. The product precipitated from the solution by the addition of ethyl acetate. The precipitate was collected by filtration and dried to give the subtitled compound (1.3 g, 91%).
後処理
- customthe solvent was evaporated in vacuo
- dissolutionthe residue redissolved in a small volume of ethanol
- customThe product precipitated from the solution by the addition of ethyl acetate
- filtrationThe precipitate was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-0a298d99e03a41c588c18607c8b057ee
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186718B2
反応ノート
読み込み中…