1-(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-yl)-2-(trimethylsilyl)ethanol → 7-Ethenyl-2,3-dihydro[1,4]dioxino[2,3-c]pyridine

HRID 456610ノート

反応式

HRID 456610 の反応式
[O:1]1[C:10]2[CH:9]=[C:8]([CH:11](O)[CH2:12][Si](C)(C)C)[N:7]=[CH:6][C:5]=2[O:4][CH2:3][CH2:2]1.CC(C)([O-])C.[K+]>O1CCCC1>[CH:11]([C:8]1[N:7]=[CH:6][C:5]2[O:4][CH2:3][CH2:2][O:1][C:10]=2[CH:9]=1)=[CH2:12]

参加物

4

反応物 2

HCID 179812561-(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-yl)-2-(trimethylsilyl)ethanolHCID 23665647Potassium tert-butoxide

生成物 1

HCID 179812417-Ethenyl-2,3-dihydro[1,4]dioxino[2,3-c]pyridine収率 145.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of (d) (1.6 g) in tetrahydrofuran (20 ml) was treated at 0° C. under argon with a solution of potassium t-butoxide in tetrahydrofuran (1M; 7.6 ml, 7.6 mmol). After 2 hours the mixture was partitioned between ethyl acetate—half saturated aqueous ammonium chloride solution. The organic extract was dried and evaporated affording an oil (1.5 g).

後処理

  1. customAfter 2 hours the mixture was partitioned between ethyl acetate—half saturated aqueous ammonium chloride solution
  2. extractionThe organic extract
  3. customwas dried
  4. customevaporated

出典と根拠

ORDレコード
ord-786376f0cc7b4dfb84dbbfb07c033888
出典データセット
uspto-grants-2007_03
特許番号
US07186730B2

反応ノート

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