Hydrazine hydrate (1:1) → HCID 178420814、化合物
反応式
Cl[C:2]1[C:7]([C:8]([C:10]2[NH:11][CH:12]=[CH:13][CH:14]=2)=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[NH:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[NH:17][N:16]=1参加物
4
実験手順
A mixture of (2-chloro-pyridin-3-yl)-(1H-pyrrol-2-yl)-methanone (1 g, 4.8 mmol) and hydrazine hydrate (0.5 mL) in ethanol (15 mL) was heated to reflux for overnight. The reaction was concentrated and the residue was triturated with dichloromethane (to remove any unreacted starting material. The solid was filtered, washed wit water and dried to give 720 mg (81%) of the titled compound as a light yellow solid.
後処理
- temperaturewas heated
- temperatureto reflux for overnight
- concentrationThe reaction was concentrated
- customthe residue was triturated with dichloromethane (
- customto remove
- filtrationThe solid was filtered
- washwashed wit water
- customdried
出典と根拠
- ORDレコード
- ord-f9cb4e804a964e21ab90878eeb1e1b60
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186716B2
反応ノート
読み込み中…