Hydrazine hydrate (1:1) → HCID 178527562、化合物

HRID 456642ノート

反応式

HRID 456642 の反応式
[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]([C:19]2[C:20](Cl)=[N:21][CH:22]=[CH:23][CH:24]=2)=O)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>C(O)C>[CH2:1]([NH:8][S:9]([C:12]1[CH:16]=[C:15]([C:17]2[C:19]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:28][N:27]=2)[NH:14][CH:13]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 865922435-(2-chloro-pyridine-3-carbonyl)1H-pyrrole-3-sulfonic acid benzylamide

生成物 1

HCID 178527562HCID 178527562、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-3-sulfonic acid benzylamide (100 mg), hydrazine hydrate (excess) in ethanol (10 mL) was heated at 80° C. for 48 hours. The reaction was concentrated, mixed with water, the precipitate was filtered off, the filtrate was washed with dilute HCl, water, dried and concentrated to give the titled compound as a light yellow solid.

後処理

  1. concentrationThe reaction was concentrated
  2. additionmixed with water
  3. filtrationthe precipitate was filtered off
  4. washthe filtrate was washed with dilute HCl, water
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-2a1b0aeb7f674e26a6736595803bf2a1
出典データセット
uspto-grants-2007_03
特許番号
US07186716B2

反応ノート

読み込み中…