Methylamine → N-Methyl-1H-pyrrole-2-carboxamide

HRID 456658ノート

反応式

HRID 456658 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.C(Cl)(=O)C(Cl)=O.[CH3:15][NH2:16]>C(Cl)Cl.CN(C=O)C.N1C=CC=C1C(Cl)=O.C(OCC)(=O)C>[CH3:15][NH:16][C:6]([C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)=[O:8]

参加物

8

反応物 3

HCID 6329MethylamineHCID 12473Pyrrole-2-Carboxylic AcidHCID 65578Oxalyl chloride

生成物 1

HCID 23273389N-Methyl-1H-pyrrole-2-carboxamide

試薬・触媒・溶媒 4

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒HCID 224558Pyrrole-2-carbonyl chloride溶媒

実験手順

To a solution of 1H-pyrrole-2-carboxylic acid (1 g, 9 mmol) (Aldrich, Milwaukee, Wis.) in DCM (15 mL) was added oxalyl chloride (1.1 mL) and DMF (3 drops). The mixture was stirred at room temperature resulting in 1H-pyrrole-2-carbonyl chloride. Methylamine (30 mmol) was then added to the acid chloride and the mixture was stirred at room temperature. The reaction was diluted with ethyl acetate, washed with brine (2×), NaHCO3, dried and concentrated to give 1H-pyrrole-2-carboxylic acid methylamide.

後処理

  1. stirringthe mixture was stirred at room temperature
  2. washwashed with brine (2×), NaHCO3
  3. customdried
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-b651e65a5daa42c48177d12dc97e29c8
出典データセット
uspto-grants-2007_03
特許番号
US07186716B2

反応ノート

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