Hydrazine hydrate (1:1) → HCID 178485302、化合物
反応式
[CH3:1][NH:2][C:3]([C:5]1[NH:6][C:7]([C:10]([C:12]2[C:13](Cl)=[N:14][CH:15]=[CH:16][CH:17]=2)=O)=[CH:8][CH:9]=1)=[O:4].O.[NH2:20][NH2:21]>C(O)C>[CH3:1][NH:2][C:3]([C:5]1[NH:6][C:7]([C:10]2[C:12]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[NH:21][N:20]=2)=[CH:8][CH:9]=1)=[O:4]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid methylamide (320 mg, 1.2 mmol) and hydrazine hydrate (2 mL) in ethanol (20 mL). The mixture was heated to at 80° C. for 48 hours. The precipitate was collected by vacuum filtration, washed with ethanol and water, dried to give 80 mg (27%) of the titled compound.
後処理
- filtrationThe precipitate was collected by vacuum filtration
- washwashed with ethanol and water
- customdried
出典と根拠
- ORDレコード
- ord-851fb82f2c894653b4361c8b20316986
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186716B2
反応ノート
読み込み中…