Acetic Acid → 2-Chloro-N-(4-methyltetrahydro-2H-pyran-4-yl) acetamide

HRID 456734ノート

反応式

HRID 456734 の反応式
[CH3:1][C:2]1(O)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.C(O)(=[O:11])C.S(=O)(=O)(O)O.[Cl:18][CH2:19][C:20]#[N:21]>>[Cl:18][CH2:19][C:20]([NH:21][C:2]1([CH3:1])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1)=[O:11]

参加物

5

反応物 4

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 7856ChloroacetonitrileHCID 123471184-Methyloxan-4-ol

生成物 1

HCID 184373262-Chloro-N-(4-methyltetrahydro-2H-pyran-4-yl) acetamide

実験手順

To a solution of 4-methyltetrahydro-2H-pyran-4-ol obtained in Example 7-1 in chloroacetonitrile (0.65 mL), was added a mixture of acetic acid and conc. sulfuric acid (1/1, 1.6 mL) dropwise with cooling on an ice bath. The reaction mixture was warmed to room temperature and stirred for 3 hrs.

後処理

  1. temperaturewith cooling on an ice bath

出典と根拠

ORDレコード
ord-194497308cdf495f949142f79cca5feb
出典データセット
uspto-grants-2007_03
特許番号
US07186731B2

反応ノート

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