Potassium Hydroxide → 4-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid

HRID 456805

反応式

HRID 456805 の反応式
[CH2:1]([O:4][C:5]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])[CH:2]=[CH2:3].[OH-].[K+]>CO.CCOC(C)=O>[CH2:1]([O:4][C:5]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])[CH:2]=[CH2:3]

参加物

5

反応物 2

HCID 14797Potassium Hydroxide2 回HCID 10242646Methyl 2-(allyloxy)-4-methoxybenzoate

生成物 1

HCID 215068784-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2 (2.5 g, 11 mmol) in aqueous methanol (30 mL) was added KOH (1 eq, 630 mg). Reaction was heated to 50° C. for 12 hours before the addition of more KOH (630 mg). After 12 hours, the mixture was cooled, diluted with EtOAc and washed with 1M HCl. Aqueous layer was extracted with EtOAc (3×). Combined organic layers, dried over Na2SO4, and concentrated. Product was isolated as an off white solid and used without further purification.

後処理

  1. customReaction
  2. temperaturethe mixture was cooled
  3. washwashed with 1M HCl
  4. extractionAqueous layer was extracted with EtOAc (3×)
  5. dry with materialCombined organic layers, dried over Na2SO4
  6. concentrationconcentrated
  7. customProduct was isolated as an off white solid
  8. customused without further purification

出典と根拠

ORDレコード
ord-7a610adfa43f42618315f674ee0c8a30
出典データセット
uspto-grants-2007_03
特許番号
US07186746B2

関連ノート

読み込み中…