tert-Butanol → 2-(2-oxo-1,2-dihydro-3-quinolinyl)-1H-indole-5-carboxylic acid

HRID 456912

反応式

HRID 456912 の反応式
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH:17]=[O:18])=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:19]1[C:20](=[O:29])[NH:21]C2C(C=1)=CC=CC=2)=O)(C)(C)C.[CH3:30][C:31]([CH2:33][CH3:34])=[CH2:32].OP([O-])(O)=O.[Na+].Cl([O-])=[O:42].[Na+].[CH3:45][C:46](O)(C)C>>[O:29]=[C:20]1[C:19]([C:9]2[NH:8][C:16]3[C:11]([CH:10]=2)=[CH:12][C:13]([C:17]([OH:18])=[O:42])=[CH:14][CH:15]=3)=[CH:30][C:31]2[C:32](=[CH:45][CH:46]=[CH:34][CH:33]=2)[NH:21]1

参加物

6

反応物 5

HCID 6386tert-ButanolHCID 112402-Methyl-1-buteneHCID 121116895-Formyl-2-(2-oxo-1,2-dihydro-quinolin-3-yl)-indole-1-carboxylic acid tert-butyl esterHCID 23668197Sodium Chlorite2 回HCID 23672064Monosodium phosphate2 回

生成物 1

HCID 226682542-(2-oxo-1,2-dihydro-3-quinolinyl)-1H-indole-5-carboxylic acid

実験手順

A solution of 2-(2-oxo-1,2-dihydro-3-quinolinyl)-1H-indole-5-carbaldehyde (5-8, 500 mg, 1.29 mmol, 1 equiv) in a 4:1 mixture of TBF and t-BuOH was treated with 2-methyl butene (8 mL), an aqueous solution of sodium phosphate monobasic (0.14 M 355.2 mg, 2.57 mmol, 2.00 equiv), and sodium chlorite (232.8 mg, 2.57 mmol, 2.00 equiv). Additional solid sodium phosphate monobasic (380 mg, 2.76 mmol, 2.14 equiv) and sodium chlorite (300 mg, 3.32 mmol, 2.57 equiv) was added in 2 equal portions over 2.5 hours. The reaction mixture was concentrated, and the residue dissolved in EtOAc (60 mL), then washed twice with a 25:1 mixture of aqueous 10% sodium bisulfite solution and 10% potassium hydrogen sulfate solution (2×50 mL). The organic layer was dried over sodium sulfate, concentrated, and combined with a precipitate in the aqueous layer which was filtered and dried to 2-(2-oxo-1,2-dihydro-3-quinolinyl)-1H-indole-5-carboxylic acid (6-1) as an off-white solid. 1H NMR (500 MHz, DMSO) δ 12.13 (s, 1H), 8.27 (s, 1H), 8.14 (m, 3H), 7.95 (d, 1H, J=7.8 Hz), 7.76 (d, 1H, J=7.8 Hz), 7.54 (t, 1H, J=7.8), 7.36 (d, 1H, J=7.8), 7.24 (t, 1H, J=7.8) 1.36 (s, 9H).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue dissolved in EtOAc (60 mL)
  3. washwashed twice with a 25:1 mixture of aqueous 10% sodium bisulfite solution and 10% potassium hydrogen sulfate solution (2×50 mL)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated
  6. filtrationwas filtered
  7. dry with materialdried to 2-(2-oxo-1,2-dihydro-3-quinolinyl)-1H-indole-5-carboxylic acid (6-1) as an off-white solid

出典と根拠

ORDレコード
ord-6a30b49de1a94188b72e41717547bbc2
出典データセット
uspto-grants-2007_03
特許番号
US07186723B2

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