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5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline → 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 9864712 | — |
| 反応物 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 溶媒 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 生成物 | 5-(2,4-Difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 22139740 | 45.9% |
反応手順
5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline 101 (230 mg) was dissolved in 9 mL (1:1:1 MeOH/THF/H2O) and was treated with 1 gram of OXONE™. After 3 hours the mixture was partitioned between CH2Cl2 and water. The product was purified by chromatography (10% MeOH/CH2Cl2) to afford 110 mg of 5-(2,4-difluoro-benzenesulfinyl)-2-methanesulfonyl-6-methoxy-quinoline 301; ([M+H]+)=398.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186840B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-450de943c60345179af302675b43c965 |
| 出典メモ | uspto-grants-2007_03 |