Carbonyl bromide → HCID 22254060、化合物

HRID 457682

反応式

HRID 457682 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14](N(C)C(N)=S)[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6].Br[C:23](Br)=O.C(N(C(C)C)CC)(C)C>CCO>[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([CH2:23][NH:1][C:2]([NH2:4])=[S:3])[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6]

参加物

6

反応物 4

HCID 79057Carbonyl bromideHCID 81531DiisopropylethylamineHCID 2723790ThioureaHCID 17946834HCID 17946834、化合物

生成物 1

HCID 22254060HCID 22254060、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A thiourea such as N-[4-(isopropylformylamino)cyclohexyl]-methylthiourea (0.029 mmol, 1 equivalent), a bromoketone (0.044 mmol, 1.5 equivalent) and 2 equivalents of diisopropylethyl amine in 10 ml of EtOH were heated at reflux temperature for 2 days. The reaction mixture was concentrated in vacuo and the crude product chromatographed (silica) to obtain the desired product. This procedure was used to prepare examples 101–102.

後処理

  1. temperatureat reflux temperature for 2 days
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe crude product chromatographed (silica)

出典と根拠

ORDレコード
ord-ee9773061a0943b58a1861525ed730a9
出典データセット
uspto-grants-2007_03
特許番号
US07189720B2

関連ノート

読み込み中…