Guanidine Hydrochloride → 4-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine

HRID 457875ノート

反応式

HRID 457875 の反応式
CN(C)[CH:3]=[C:4]([C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.[NH2:20][C:21]([NH2:23])=[NH:22].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)=[CH:3][N:20]=[C:21]([NH2:23])[N:22]=1

参加物

6

反応物 3

HCID 5742Guanidine HydrochlorideHCID 11430Potassium CarbonateHCID 670738543-(Dimethylamino)-1-(furan-2-yl)-2-(pyridin-4-yl)prop-2-en-1-one

生成物 1

HCID 97947204-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine収率 80%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A suspension of 3-(dimethylamino)-1-(2-furyl)-2-(4-pyridyl)-2-propene-1-one (2.2 g, 9.08 mmol), guanidine hydrochloride (2.6 g, 27.2 mmol) and potassium carbonate (7.5 g, 54.3 mmol) in N,N-dimethylformamide (20 mL) was stirred at 70° C. for 12 hours. After cooling as it was, the reaction mixture was diluted with water. The resulting crystals were collected by filtration and washed with water, to give the title compound (1.73 g, 80%) as a pale yellow solid.

後処理

  1. temperatureAfter cooling as it
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-6d8106a2920646acb514d843bfc9b85c
出典データセット
uspto-grants-2007_03
特許番号
US07189717B2

反応ノート

読み込み中…