Hydrochloric Acid → 2-(Isopropylsulfonyl)ethanamine

Prepared according to Procedure K. 2-iso-Propylsulfonylacetonitrile (0.50 g, 3.39 mmol) was dissolved in THF and warmed to reflux under N2. Borane dimethylsulfide (2M, 1.7 mL, 3.39 mmol) was added dropwise and the reaction was stirred for an additional 40 minutes at reflux. After cooling the reaction to rt, HCl (2 M in MeOH) was added to the reaction slowly due to gas evolution. The volatiles were removed and frexh methanol was added to the resulting residue. Again, the volatiles were removed and the resulting residue was taken up in CH2Cl2 (25 mL) and washed with saturated potassium carbonate (aqueous). The organic layer was dried over sodium sulfate and the volatiles were removed to afford the title compound. GC-MS m/z 152 (MH+).

1. customPrepared
2. temperaturewarmed
3. temperatureto reflux under N2
4. temperatureat reflux
5. temperatureAfter cooling
6. customthe reaction to rt
7. customThe volatiles were removed
8. additionfrexh methanol was added to the resulting residue
9. customAgain, the volatiles were removed
10. washwashed with saturated potassium carbonate (aqueous)
11. dry with materialThe organic layer was dried over sodium sulfate
12. customthe volatiles were removed

ORDレコード

ord-3fe05e38b9c843a6a6664e4f6a845de0

出典データセット

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07189734B2