Acetic Acid → HCID 67973461、化合物
反応式
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[CH:7][C:6]=1[Br:18])(=O)C.[OH-].[Na+].C(O)(=O)C>CO>[Br:18][C:6]1[CH:7]=[C:8]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH:9]=[CH:10][C:5]=1[OH:4]参加物
5
実験手順
2-bromo-4-(4-methylpiperazin-1-yl)phenyl acetate 280 mg (1.03 mmol) were dissolved in methanol and reacted with 2 ml of 1 N NaOH. After two hours the reaction was acidified with glacial acetic acid, evaporated and purified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH. LC/MS (m/z): 273.2 [M+H]+, HPLC (254 nm) method 3 Rt 2.96 min.
後処理
- customevaporated
- custompurified on silica with DCM/MeOH 9/1 0.4% 7M NH3 in MeOH
出典と根拠
- ORDレコード
- ord-c6643483d84745b4946092962a1949c5
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541576B2
反応ノート
読み込み中…