HCID 178526612、化合物 → HCID 178507541、化合物

HRID 45813

反応式

HRID 45813 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[N:18]1[CH:17]=[CH:16][C:15]([C:14]2[C:10]([C:6]3[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=3)=[N:11][NH:12][CH:13]=2)=[CH:20][CH:19]=1

参加物

4

反応物 1

HCID 178526612HCID 178526612、化合物

生成物 1

HCID 178507541HCID 178507541、化合物収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1.27 g (4.77 mmol) of 4-[3-(3-nitro-phenyl)-1H-pyrazol-4-yl]-pyridine was suspended in methanol (200 mL). Pd/C 10% (250 mg) was added and the mixture was agitated under hydrogen pressure (50 psi) in a Parr apparatus at room temperature for 4 hours. The catalyst was then filtered on a Celite pad and washed with methanol. The filtrate was concentrated to dryness to obtain 1.1 g (98% yield) of 3-(4-pyridin-4-yl-1H-pyrazol-3-yl)-phenylamine as an off-white solid.

後処理

  1. filtrationThe catalyst was then filtered on a Celite pad
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-fd89aa0474bd4d428b81fa8a470d17d1
出典データセット
uspto-grants-2013_09
特許番号
US08541575B2

関連ノート

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